Box design varies.
From the manufacturer:
Kleenex® is the #1 tissue trusted by teachers* and Ultra Soft™ Tissues have 3 thick layers that softly comfort skin and keep hands protected all school year long. Ultra Soft™ is hypoallergenic and allergist-approved for every achoo. They’re dye-, fragrance-, and lotion-free, so they work just as well for watery eyes as they do for runny noses! All Kleenex® Brand Tissues are made from 100% responsibly sourced fiber, and our cartons feature bright, colorful designs that are sure to pop in your classroom!
During every back-to-school season, Kleenex teams up with Donors Choose to donate a portion of every Kleenex® purchase. To date, Kleenex® has donated over $4 million dollars to help support under-funded classrooms in low-income communities because every child should have the chance to thrive.